Beyond (membrane) boundaries: Study reveals endosomal GPCR activity
Author
: Samir Amin
Blog
: Blog Junction | SBAmin.com
Date
: 3/21/2013 7:00:00 AM
'Exosome formation pathway - Image from Wikipedia.orgG-Protein Coupled Receptors (GPCR) are one of the most fascinating and intriguing type of receptors with wide range of influence in intra-cellular signaling pathways. Besides well-characterized plasma membrane bound GPCR functions, new study now reveals intra-cellular mode of triggering endosome-bound GPCR signaling to downstream regulators.thoughts: This is of particular importance in possibly more complex and widespread modulatio(...)'
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Tips for working in R - automatically install missing package
Author
: Samir Amin
Blog
: Blog Junction | SBAmin.com
Date
: 11/6/2012 12:42:00 AM
'Moved to http://sbamin.com/2012/11/05/tips-for-working-in-r-automatically-install-missing-package/ Posted by Samir Amin'
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The other side of reprogramming: Origin of GBM from non-glial cells
Author
: Samir Amin
Blog
: Blog Junction | SBAmin.com
Date
: 10/24/2012 5:49:00 AM
'Researchers at Salk institute show reprogramming of variety of neuronal cells to malignant glioma (mesenchymal) upon oncogenic addiction."Our findings," says lead author Dinorah Friedmann-Morvinski, a postdoctoral researcher in the Laboratory of Genetics, "suggest that, when two critical genes—NF-1 and p53—are disabled, mature, differentiated cells acquire the capacity to reprogram [dedifferentiate] to a neuroprogenitor cell-like state, which can not only maintain their plasticity, (...)'
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"Junk" DNA gets the credit - ENCODE results are out
Author
: Samir Amin
Blog
: Blog Junction | SBAmin.com
Date
: 9/5/2012 11:33:00 PM
'The ENCODE consortium has just published comprehensive draft of gene regulatory elements in 30 research articles across several journals. NY Times has a nice summary and Nature magazine has created a dedicated web-portal to scan through all published results. Published data can be downloaded at ENCODE website, http://genome.ucsc.edu/ENCODE/ Posted by Samir Amin'
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Writing a qualifying exam proposal
Author
: Samir Amin
Blog
: Blog Junction | SBAmin.com
Date
: 8/13/2012 8:59:00 PM
'After a year long hiatus in managing twin transition, I am back into truly updating this blog besides cross-posting and micro-blogging buzz in the cancer research. As I am gearing up for the upcoming qualifying exam, I thought to post my custom made "unofficial" guide for writing a qualifying exam proposal. It is primarily based on guide for writing a grant proposal from NIH as well as recommendations from SCBMB graduate department at Baylor College of Medicine.Qualifying Exam (QE) (...)'
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